• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
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    • 专利摘要:
    The composition is based on the active role of certain dietary fibers as functional food ingredients in combination with a mixture of enzymes that promote the functioning of the intestinal flora and in addition with a supporting mixture of nutrients to promote the restoration of colonocytes.
    公开号:BE1020284A3
    申请号:E2011/0607
    申请日:2011-10-17
    公开日:2013-07-02
    发明作者:Saeid Bathaei
    申请人:Biotechnobel；
    IPC主号:
    专利说明:

    Composition to obtain positive health effects.
    The present invention relates to a composition for obtaining beneficial health effects.
    The action of the composition is based on the active role of certain dietary fibers as functional food ingredients that, in combination with a mixture of enzymes, optimize the functioning of the intestinal flora and in addition with a supporting mixture of nutrients that support the restoration of colonocytes.
    Dietary fiber is an important part of a healthy and balanced diet and their role in the digestion and metabolism of food is being investigated more and more, although some aspects of the biological effects are not yet fully understood. However, nutritionists agree that dietary fiber is beneficial to public health and an essential part of any well-balanced diet.
    The food fibers are generally regarded as an indigestible part of a plant or vegetable diet. They are carbohydrates, more specifically non-starchy poly- and oligosaccharides and lignin that is mainly derived from cell walls of plants and that cannot be hydrolyzed by human digestive enzymes. However, they can often be fermented by intestinal bacteria to produce hydrogen, methane, carbon dioxide, water and short-chain fatty acids (SCFA).
    The classification of dietary fiber can be based on various parameters. For example, they can be classified according to their fermentability or viscosity, but in general the classification is based on their solubility. Hereby, the dietary fiber is divided into two different categories, namely insoluble and soluble dietary fiber. Both types have different structures and functions and are beneficial to human digestion.
    The insoluble fibers are metabolically inert, but have effect by absorbing water in the digestive system, and thereby relieving defecation. The primary benefits of these types of fibers are therefore that they have a regulatory effect and relieve constipation.
    The soluble fibers are those that can be fermented in the colon (colon). These are also the fibers that endogenous bacteria convert into gases and physiologically active by-products.
    In the large intestine, the fibers mainly serve as a substrate for microorganisms of the intestine. The epithelium of the colon, the importance of which is increasingly recognized in public health, is an ideal environment for endogenous microorganisms. In addition to direct access to food, the epithelium provides a supportive base for the endogenous bacteria to which they can optimally attach themselves.
    The soluble dietary fibers in the large intestine that cannot be hydrolyzed by human enzymes are hydrolyzed by intestinal bacterial enzymes and are also digested by these endogenous bacteria. By doing this, these bacteria will produce hydrogen, methane, short-chain fatty acids, etc. The short-chain fatty acids in particular are very beneficial to health and thus form one of the most important benefits of dietary fiber.
    The short-chain fatty acids (SCFA) are by-products of the fermentation of soluble fibers in the colon. SCFA are involved in numerous physiological processes and promote health. Among other things, they stabilize blood glucose levels by acting on pancreatic insulin release and liver glycogen control. They provide nutrition to colonocytes, in particular the SCFA butyrate, they reduce blood levels of LDL cholesterol and triglyceride responsible for atherosclerosis, they reduce colon pH, promote T helper cells, antibodies, etc. and improve barrier properties of the mucose layer of the colon.
    The production of SCFA is one of the main reasons why dietary fiber is so beneficial to our health.
    The oligosaccharides are an important class of soluble fibers. They are formed from short to medium-sized sugar polymers. When oligosaccharide fibers are consumed, the undigested portion serves as food for the intestinal flora. Depending on the type of oligosaccharide, different bacterial groups are promoted or suppressed. Several clinical studies have shown that the administration of oligosaccharides can increase the number of friendly or beneficial microorganisms while reducing the population of harmful microorganism bacteria.
    The Fructo-oligosaccharides (FOS) are mainly found in vegetables and consist of short chains of fructose molecules. Inulin, another dietary fiber, has about the same structure as FOS and also consists of fructose molecules. However, it is polymerized much more strongly and is therefore considered a polysaccharide.
    Other oligosaccharide fibers are Xylooligosaccharides (XOS) which consist of mannose and xylose units, respectively. Xylooligosaccharides are beneficial to health for a variety of reasons. For example, they support the selective growth of beneficial species of Bifidobacterium and Bacteroides, which have important biological effects, due to the production of SCFA and they facilitate the absorption of nutrients. Xylo-oligosaccharides are considered to be very beneficial to health compared to other non-digestible oligosaccharides. They occur naturally in fruits, vegetables, bamboo, honey and milk and can be produced on an industrial scale from xylan-rich materials.
    Dextrins are Gluco-oligosaccharides (GOS), a linear complex of oligosaccharides that cannot be hydrolyzed by amylolytic enzymes, and hence are considered fibers with potential positive effects on the gut flora.
    Several dietary fibers, such as oligosaccharides discussed, have also been defined as prebiotics. To be classified as prebiotic as a food ingredient, it must meet the following criteria: i) neither hydrolyzed nor absorbed in the upper gastrointestinal tract, ii) selectively fermented by one or a limited number of potentially beneficial intestinal bacteria commensally to the colon, and iii) can change the gut flora to a healthier composition, by increasing friendly bacteria and reducing harmful gut flora.
    Since dietary fiber provides such a wide range of nutritional and health benefits, it is no surprise that they are added to many foods and provided as separate food supplements or prebiotic compounds.
    For example, WO 2007/050656 A2 describes a food supplement based on dietary fiber. The food supplement is a fiber formulation that in its primary embodiment comprises partially hydrolyzed guar gum (PHGG) and Fructo-oligosaccharides (FOS), wherein the combination has a greater prebiotic effect than a prebiotic potential of PHGG and FOS individually.
    WO 2004/052121 describes prebiotic compositions containing soluble fibers, in particular Fructo-oligosaccharides (FOS) and galacto-oligosaccharides and their use in the treatment of prevention of gastrointestinal tract imbalances, such as diarrhea, constipation and inflammatory bowel disease (IBD).
    US2008 / 0261919A1 describes synergistic compositions with components selected from a broad group including modified or unaltered starch or partially hydrolyzed versions thereof, fructo-oligosaccarides, trans-galacto-oligosaccarides, xylo-oligosaccarides (XOS), beta-glycan and partially hydrolysed versions and, if desired, other plant extracts, mineral components, vitamins, and additives.
    All of the compositions described above relate to prebiotic mixtures of dietary fibers and provide some beneficial effect on health by stimulating the microorganisms in the colon. However, none of the compositions manage to promote the micro-bacterial gut flora in an optimal manner.
    WO 2007/050656 A2 describes a synergistic effect by mixing partially hydrolyzed guar gum (PHGG) and Fructo-oligosaccharides (FOS). However, this effect is small, and although the mixture is fermented selectively and promotes some beneficial intestinal bacteria, this effect is not evenly distributed among all beneficial bacteria. Some bacteria will be highly promoted while others, for example, good bacteria suitable for slowly metabolizing FOS or PHGG, will be overgrown by the overly stimulated bacteria. Therefore, the beneficial microbial flora will not be very diverse and will only include a few species.
    WO 2004/052121 describes a mixture of FOS and galacto-oligosaccharides and their beneficial effects, as well as the synergy between these two prebiotic fibers. In other preferred embodiments, other prebiotic oligosaccharides such as XOS are also included in the composition.
    As mentioned above, US2008 / 0261919A1 describes a composition comprising a wide variety of dietary fibers.
    These last two publications thus describe compositions comprising multiple prebiotic compositions, and will thus provide a more varied diet for beneficial bacteria.
    However, since the metabolic rates at which the different bacteria break down these different prebiotic fibers are still dependent on several factors, such as species variation, the growth of these different bacteria will not yet be promoted proportionally. As a result of all this, there will be a lack of diversity in the healthy microbial flora and the positive health aspects such as better food digestion etc. will be limited.
    Thus, there is a need for a composition that promotes a wider range of beneficial microorganisms and more also promotes these various species.
    It is therefore an object of the present invention to provide a composition that offers a general broader prebiotic activity and also more optimally promotes a beneficial gut flora.
    To this end, the composition comprises dietary fibers as functional food ingredients in combination with a mixture of enzymes that optimize the functioning of the intestinal flora and in addition with a supporting mixture of food ingredients to aid in the restoration of colonocytes.
    To this end, more than one type of dietary fiber is used. More specifically, more than one type of oligosaccharides is used in the composition to restore the balance of the intestinal flora. The different types of dietary fiber present in the composition of the present invention allow to promote a higher number and a wider range of types of the beneficial gut flora. This makes it possible to preserve the biodiversity of the flora.
    According to the present invention, the dietary fibers comprise a mixture of Xylooligosaccharides (XOS) and / or xylane, fructooligosaccharides (FOS), and Glucooligosaccharides (GOS).
    These dietary fibers comprise a broad and varied mixture that will promote a diverse group of beneficial bacteria such as various species of bifidobacteria and / or lactobacillus but also the very important group of bacteroides. Inulin is a polymer that will be split into FOS by the bacterial enzymes and will have similar prebiotic activity. Although the number of different types of dietary fiber in this composition is still rather limited, these specific types of fibers offer very beneficial effects for the gut flora, and a wide variety of different desired microorganisms will be promoted. FOS is used by bacteroides and lactobacillus. The presence of pectinase initially helps bacteroides to digest the FOS fibers. This gives them an extra incentive.
    Xylo-oligosaccharides give an additional beneficial effect. Xylo-oligosaccharides offer advantages over other non-digestible oligosaccharides in terms of both health and technological properties. Xylans are chemically complex, and their degradation requires multiple enzymes. The expression of these enzymes by the intestinal bacteria varies considerably from one species to another. The polysaccharides of cellular walls of plants (insoluble fiber) are not hydrolyzed in the stomach and small intestine. After reaching the colon, these materials are used as a source of fermentable carbohydrate available for the endogenous bacteria. The types of bacteroides form an important part of the bacterial population of the colon. In the human colon, bacteroides are important xylanolytic bacteria. They can ferment Xylans and thus use Xylans as the primary source of carbohydrate.
    It has been found that Xylo-oligosaccharides selectively support the growth of microorganisms in the human colon, in particular, Bacteroides and prevent the production of acid by Streptococci. In addition, the XOS and FOS supplements significantly stimulate the growth of bifidobacteria lactobacillus in the appendix. In addition, XOS and FOS have a positive influence on metabolic disorders related to diabetes.
    Dextrins are Gluco-oligosaccharides (GOS), a linear complex of gluco-oligosides (oligoside of glucose) that cannot be hydrolyzed by the amylolytic enzymes. The shortest dextrin is isomalosis made from 2 units of glucose.
    Gluco-oligosaccharides are mainly composed of glucose. The hydrolysis of starch produces gluco-oligosides.
    From the point of view of digestibility, gluco-oligo saccharides have a special alpha (1-2) compound on the non-reducing end of the oligosaccharide that makes it possible to block the hydrolytic action of saliva and of intestinal digestive enzymes. Consequently, they reach the colon intact. The GOS molecules are digested with the help of Invertase. Invertase is an enzyme produced in small quantities by the human body. For efficient use by bacteria, additional Invertase is preferred in the formula.
    Gluco-oligosaccharides (GOS) belong to the group of prebiotic fibers that promote the growth and / or the activity of beneficial bacteria in the colon.
    A balanced intestinal flora plays an important role in the natural defenses of the human body. Gluco-oligosaccharides support the body's natural defenses through the intestinal flora and indirectly inhibit the binding of Escherichia coli, salmonella typhimurium and Clostridium to the colon. Thus reduces the risk of infection and interacts directly with the immune cells that can potentially prevent allergies and reduce infectious diseases.
    Constipation is a frequent problem, especially among the elderly and pregnant women. For these individuals, the consumption of gluco-oligosaccharides can help with their symptoms.
    Gluco-oligosaccharide is the oligosaccharide that is more easily consumed by bacteroides and bifidobacteria than by clostridium. Even if these 3 families are a normal combination in an average individual, the Clostridium can be considered as not beneficial for intestinal balance.
    These elements confirm that Gluco-oligosaccharides are a good substrate for the Bacteroides population, and that their consumption supports the growth of those elements that are unfavorable to other prebiotic compositions that preferentially promote bifidobacteria.
    Preferably, the mixture comprises 20% by weight from FOS, 30% by weight GOS and 50% by weight for both together in the mixture. We have found that the stimulus of such a mixture supports a wide range of good microorganisms in a balanced way. Although these values are preferred, it has been found that similar benefits are observed within the following ranges: 15-25% by weight, FOS, 25-35% by weight, GOS and 45-55% by weight relative to the total. The sum is always 100%.
    The composition of the present invention includes not only the dietary fiber that has prebiotic beneficial health effects. It also includes at least one enzyme suitable for breaking down these dietary fibers.
    In this way the enzyme will split the fibers and divide these fibers into smaller fiber fragments, mainly oligosaccharides, perhaps also in di- and monosaccharides that can be digested more easily and faster by the different types of beneficial bacteria. In the case of inflammatory bowel disease (IBD), these enzymes are no longer produced by the intestinal bacteria and therefore help is needed. Therefore, the composition of the present invention will provide broadly appropriate prebiotic activity that will activate the beneficial microbial population in an optimum manner and offer them a selective growth advantage as compared to non-beneficial gut bacteria, such as coliforms, Clostridum, sulfate-reducing bacteria, etc.
    The composition of the present invention will have a further advantage over compositions that contain partially hydrolyzed fibers, i.e., fibers that have already been split, such as those described in US2008 / 0261919A1. Because such enzymes in the composition of the present invention generally become slowly active as they enter our gastrointestinal tract, hydrolysis will occur primarily in the large intestine. Therefore, only a smaller portion of hydrolysed fibers will be digested by microorganisms in the small intestine. This is in contrast to compositions that contain fibers that have already been hydrolyzed outside of our body such as US2008 / 0261919A1. In these compositions, the fibers enter our gastrointestinal tract in a hydrolyzed and spliced state, resulting in a massive digestion in the small intestine such that they can no longer lead to gel formation. The composition of the present invention will thus have a more efficient prebiotic action compared to compositions containing hydrolyzed fibers.
    In a preferred embodiment of the present invention, the added enzyme can digest those types of dietary fiber that are more difficult to metabolize through the beneficial endogenous intestinal bacteria than other dietary fiber-only compositions.
    As such, the enzyme will promote the growth of bacteria that feed primarily on those fibers that are more difficult to metabolize and that, therefore, often grow slower. As such, these microorganisms will be able to grow faster and compete with the other beneficial bacteria. Therefore, a more diverse beneficial gut flora will develop, thereby further improving many of the known beneficial health effects.
    An increased diversity in the intestinal flora is a significant advantage and obtainable is an important subject of this invention. The stimulation of only one microbial species, which often occurs with traditional food supplements, can cause a predominance of this one species in the gut flora and a reduction of other species and thus reduce the biodiversity of the flora, that a number of intestinal diseases such as several metabolic diseases cause further illnesses.
    Since microorganisms that mainly live on hard-to-digest fibers use these other substrates, they often have a specific metabolism and often produce other important by-products such as specific SCFAs that are hardly produced by the other beneficial bacteria. A more diverse beneficial bacterial population (ecosystem) will thus offer a wider beneficial activity that has a very positive influence on both digestion and on general health.
    In a further preferred embodiment of the present invention, Xylanase is added as an enzyme.
    The human body does not produce xylanase. This belongs to the family of glucanase enzymes characterized by their ability to cleave various Xylans into short chain Xylo-oligosaccharides such as xylose. This enzyme is important for the smooth digestion of fibers. Xylanase liquefies cell wall polysaccarides from vegetable cells, more specifically with cereals. Scientific studies with animals show that xylanase reduces the population of certain pathogenic bacteria, in particular salmonella.
    In the human colon, bacteroides are important xylanolytic bacteria. They can ferment Xylans and use them as the primary source of carbohydrate.
    Although xylans and Xylo-oligosaccharides XOS both provide substantial health benefits, as explained above, and are very important food sources for some important beneficial bacteria, it still remains difficult for these bacteria to metabolize them, or their metabolism is rather slow, causing these bacteria have a selective disadvantage compared to beneficial bacteria that feed primarily on other types of dietary fiber. Especially Bacteroides species such as Bacteroides fragilis, bacteroides Eggerthii and Bacteroides ovatus, which feed mainly on xylan, have difficulty competing with other microorganisms in terms of growth. Therefore, the enzyme added to the composition is preferably xylanase. Xylanase will further break down XOS and xylans to give those bacteria that mainly live on these fibers the chance to metabolize their food faster and grow faster and thus compete with the other beneficial bacteria.
    Therefore, these beneficial bacteria will be stimulated more strongly with the composition according to the present invention than with the compositions according to prior art and thus a more diverse and healthier intestinal flora is obtained.
    Pectin is another polysaccharide dietary fiber with a complex structure that is made up of, among other things, galacturonic acid. However, it is preferable not to have pectin as a substrate for the bacterial flora in the colon in the case of inflammatory bowel disease (Inflammatory Bowl disease). In a more preferred embodiment, this is prevented by adding pectinase to the composition to increase the digestion of pectin in the small intestine.
    Pectinase is a generic term for the enzymes that can hydrolyze pectin. The pectinase enzymes are exopolygalacturonases, pectinase, methyl esterases and lyases. Pectinases hydrolyze pectin. They reduce the number of toxic metabolites such as ethanol produced during fermentation of pectin.
    In a further preferred embodiment of the present invention, the composition comprises additional enzymes to improve digestion in the small intestine.
    These additional enzymes do not digest the fibers used in the composition of the present invention. They are more likely to help digest nutrients such as starch, fats or some sugars such as lactose in the small intestine. Preferably, all digestible foods that are normally absorbed by the human body are digested into the small intestine so that only the indigestible portion of the food (including dietary fiber) is passed on to the colon. If a substantial portion of digestible foods end up in the colon, various health problems and illnesses could occur. The additional enzymes of the composition of the present invention are preferably identical or functionally similar to enzymes naturally occurring in the small intestine. As such, these additional enzymes provide a strengthening of the natural enzymes and thus improve the capacity of the small intestine to digest nutrients.
    The benefits of adding these extra enzymes to the composition are better digestion in the small intestine and a reduced amount of non-digestible foods in the large intestine. As a result, there will be a decrease in beneficial intestinal bacteria in the large intestine since they feed on these non-digestible foods. Furthermore, bowel problems that are largely dependent on the amount of starch in the colon are eliminated. The addition of these extra enzymes will thus provide a better overall digestion and a healthier gastrointestinal tract.
    The additional enzymes are preferably selected from the group of lactase, pectinase, amylase, amyloglucosidase, lipase, xylanase and combinations of two or more thereof.
    The best solution is when all of the above enzymes are used in the composition of the present invention.
    In a preferred embodiment of the present invention, the composition is provided in a dry formulation.
    In a dry formulation, the shelf life will be longer and the enzymes will be inactive. This will eliminate the risk that the enzymes would begin to cleave the fibers before the mixture enters the human gastrointestinal tract.
    The composition is thus preferably provided in a formulation such as a powder, perhaps in e.g. a tablet or pill is compressed or in e.g. a gelatin capsule is encapsulated. As such, the different components will be in a dry matrix, unable to interact with each other.
    The composition is further protected against premature enzymatic degradation because the enzymes used therein are generally heat sensitive. As such, their optimum temperature is 37 ° C, or the human body temperature. The risk that the composition of the present invention is degraded too early when stored in a dry environment at room temperature is thus minimal.
    The composition comprises at least one food that directly supports the large intestinal epithelial cells.
    Preferably the foods of the following group are selected namely glutamine, vitamin A, vitamin C, vitamin D, vitamin E, vitamin B6, vitamin B9, vitamin B12, zinc and combinations thereof.
    For example, glutamine helps to improve the functions of the intestinal wall by promoting the proliferation of enterocytes and colonocytes. The healthy bacteria adhere better to healthy colonocytes and thus contribute to the barrier function of the colon wall.
    Vitamin A is also involved in the immune system and as such can prevent certain diseases. In combination with Zinc, and glutamine, it will also reduce intestinal permeability. Vitamin C on the one hand plays an important role in the immune system by working as an anti-oxidant. As such, it can reduce chronic inflammation caused by oxidative stress.
    The amount of glutamine in the composition is further preferably 2-10% by weight, preferably 5-10% by weight, in relation to the total weight of the composition.
    Glutamine is an important food that has several beneficial health effects as described above. Therefore, the weight percentage of glutamine is preferably higher than that of the other foods.
    The amount of enzymes in the composition is preferably 1-5% by weight, preferably 2-3% by weight with respect to the total weight of the composition.
    In this context, the total amount of enzymes refers to the total amount of both fiber fattyifying and the other additional enzymes. Since the enzymes are biocatalysts, a small amount will suffice to provide necessary enzymatic activity in the intestines.
    The amount of vitamins and minerals in the composition is preferably 0.1-5% by weight, preferably 1-3% by weight, with respect to the total weight of the composition.
    The cofactors such as vitamins and zinc can already provide sufficiently beneficial health effects in such small amounts.
    In further preferred embodiments of the present invention, beneficial health effects are expected for digestion, treatment of diarrhea, treatment of constipation, treatment of irritable bowel syndrome, treatment of inflammatory bowel disease, treatment of Crohn's disease, treatment of obesity, treatment of dyslipidemia, and combinations of two or more thereof.
    The composition can thus be used for various different purposes, such as those described above. The composition can be used, for example, to improve digestion, but it is also quite beneficial in the treatment of more complex diseases such as Crohn's disease, inflammatory bowel disease, etc.
    However, the invention is not limited to this group. The skilled person can devise a whole range of applications for the described composition.
    The composition of the present invention is taken with a daily dose of 5-20 g, preferably 5-10 g per day.
    The required dose can be further determined by the skilled person. For example, in case the composition is used as a food supplement for a healthy person to improve digestion or to provide a general healthier intestinal flora, 5 g per day should be sufficient.
    The composition is furthermore preferably suitable for daily intake.
    When taken daily, the gut flora will often be stimulated with an almost continuous stream of ingredients of the composition of the present invention that are delivered to the gut flora. As such, a daily intake will provide optimally beneficial health effects.
    The invention will be further elucidated by one example of a designated embodiment of the composition given below.
    The various components of the designated compositions and their precise amounts will be given in table form.
    Example 1:
    Table 1: The ingredients of the designated composition of Example 1 expressed in percent by weight relative to the total weight of the composition.
    The composition according to example 1 comprises FOS, GOS and XOS as dietary fibers and thus offers a wide and varied mixture that stimulates a diverse group of beneficial bacteria such as various species of bifidobacteria, bacteroides and / or lactobacillus. These specific types of fibers offer very beneficial effects for the intestinal flora and a wide variety of different beneficial microorganisms will be promoted.
    In addition to the synergistic prebiotic effects of FOS (Fructo-oligosaccharides) and GOS (gluco-oligosaccharides), Xylo-oligosaccharides (XOS) provide an additional beneficial effect to this mixture. XOS are considered to be better than other non-digestible oligosaccharides and will specifically support the selective growth of species such as Bifidobacterium, Bacteroides fragilis, Bacteroides Eggerthii and Bacteroides ovatus.
    In total, these dietary fibers represent 91% by weight of the composition and are thus the most important part of this mixture.
    Xylanase is added as an enzyme that will help digest the XOS fibers in the colon, and as such primarily promote the bacterial species that have difficulties competing with other bacteria in the gut flora.
    Other enzymes added to the composition of Example 1 are pectinase, lactase, amylase and amyloglucosidase, lipase and xylanase.
    Pectinase is another enzyme that digests dietary fiber, more specifically pectin, a dietary fiber that often occurs in a normal diet. As such, pectinase will improve the digestion of pectin in the colon, and prevent the formation of toxins, and thus further promote a beneficial gut flora.
    Lactase, amylase and amyloglucosidase are additional enzymes that are added to the composition to improve digestion in the small intestine. They naturally strengthen the enzymes occurring in the small intestine and improve the digestion of lactose and starch. Furthermore, they prevent lactose or starch from reaching the colon where they could cause health problems or illnesses.
    In total, all enzymes and additional enzymes synthesized in the composition of Example 1 represent 2.12% of the total composition.
    5.6 weight% glutamine and 1.3 weight% vitamins (A, C, D, E, B6, B9) and minerals (Zinc) are added to the composition. These foods will promote the proliferation of enterocytes and colonocytes.
    The composition of Example 1 is preferably taken daily in a dose of 5 g / day. If the composition is administered to people suffering from metabolic diseases, the dose is preferably increased to 20-25 g / day.
    权利要求:
    Claims (12)
    [1]
    A composition for obtaining positive health effects based on the active role of certain dietary fiber as functional food ingredients in combination with a mixture of enzymes that optimize the functioning of the intestinal flora and in addition with a mixture of dietary supplements to restore colonocytes, in which the dietary fibers comprise a mixture consisting of Xylo-oligosaccharides (XOS) and / or xylane, fructo-oligosaccharides (FOS) and Gluco-oligosaccharides (GOS) and wherein at least one of the enzymes can break up (digest) at least one type of these dietary fibers.
    [2]
    Composition according to claim 1, characterized in that the mixture comprises 20% by weight of FOS, 30% by weight of GOS and 50% by weight. up to the total weight of the mixture.
    [3]
    A composition according to claim 1 or 2, wherein the enzyme can digest those types of dietary fiber that are more difficult to metabolize by the beneficial endogenous intestinal bacteria than other dietary fibers (xylanase).
    [4]
    A composition according to any one of the preceding claims, where the food is selected from the group consisting of glutamine, vitamin A, vitamin C, vitamin D, vitamin E, vitamin B6, vitamin B9, vitamin B12, zinc and combinations thereof.
    [5]
    The composition of any one of the preceding claims, wherein the enzyme is selected from the group of xylanases, pectinases and combinations of two or more thereof.
    [6]
    A composition according to any one of the preceding claims, wherein additional enzymes from the group lactase, amylase, amyloglucosidase, lipase and combinations of two or more thereof are selected.
    [7]
    A composition according to any one of the preceding claims, wherein the amount of dietary fibers constitutes 50-99% by weight, preferably 70-95% by weight, more preferably 80-95% by weight with respect to the total weight of the composition.
    [8]
    A composition according to any one of the preceding claims, wherein the amount of glutamine is 2-10% by weight, preferably 5-10% by weight, with respect to the total weight of the composition.
    [9]
    The composition of any one of the preceding claims, wherein the amount of enzymes is 1-5% by weight, preferably 2-3% by weight with respect to the total weight of the composition.
    [10]
    A composition according to any one of the preceding claims, wherein the amount of vitamins and minerals is 0.1-5% by weight, preferably 1-3% by weight, with respect to the total weight of the composition.
    [11]
    A composition according to any one of the preceding claims, wherein the beneficial health effects relate to or improve digestion, treatment of diarrhea, treatment of constipation, treatment of irritable bowel syndrome, treatment of inflammatory bowel disease, treatment of Crohn's disease, treatment of obesity, treatment of dyslipidemia, and combinations of two or more thereof.
    [12]
    A composition according to any one of the preceding claims for intake at a dose of 5-20 g per day, preferably 5-10 g per day.
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    同族专利:
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    US7687487B2|2007-04-19|2010-03-30|Bionumerik Pharmaceuticals, Inc.|Camptothecin-analog with a novel, “flipped” lactone-stable, E-ring and methods for making and using same|GB2507472A|2012-09-13|2014-05-07|Ajit Ramanial Patel|Enzyme composition for enhancing digestion|
    EP3125913A1|2014-04-04|2017-02-08|Biotechnobel SA|Composition for prevention and/or treatment of chronic inflammation and concomitant biofilms in the gastrointestinal tract|
    CN109259005A|2018-11-27|2019-01-25|江苏朸健生命科技发展有限公司|Beverage composition for treating dental erosion, liquid beverage and preparation method thereof|
    CN112971156A|2021-04-08|2021-06-18|北京天葡庄园农业科技发展有限公司|Grape leaf dietary fiber extract and preparation method thereof|
    法律状态:
    2018-08-22| MM| Lapsed because of non-payment of the annual fee|Effective date: 20171031 |
    优先权:
    申请号 | 申请日 | 专利标题
    EP20110151899|EP2478779A1|2011-01-24|2011-01-24|Composition for providing beneficial health effects|
    EP11151899|2011-01-24|
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